We have an endocannabinoid system (ECS) that internally produces cannabinoids. These compounds are essential to maintaining internal balance through many different body systems. Marijuana contains a much higher THC content than hemp and contains other chemicals that can aid and bolster the therapeutic benefits of CBD. A cannabis Sativa plant will also have higher levels of pure CBD than hemp plants. Cannabidiol CBD is a chemical found in marijuana, and the cannabis plant is used to manage various health conditions such as inflammatory and neuropathic pain.
- As reviewed below, published reports focused mainly on evaluating the effects of CBD on the reinforcing and motivational actions of amphetamine, methamphetamine, and cocaine in different animal models (Table 4).
- Drought, flooding, heat or cold can all result in unintentional spikes in THC.
- Ren et al studied the postmortem brain of rats and found that CBD normalized the heroin-induced changes in CB1 receptor mRNA expression and AMPA GluR1 in the nucleus accumbens, even after 2 weeks of treatment.
- In 2014, a rodent study showed that CBD might help people retain the ability to recognize familiar faces.
Neurobiological Mechanisms Involved in CBD-Mediated Regulation of Addiction
When you ingest CBD, it interacts with a system of enzymes known as Cytochrome p450 (CYP450). These enzymes are responsible for the metabolism of drugs from pharmaceutical medications. CBD is the inhibitor of CYP45, preventing these compounds from being properly processed in the liver. According to the aforementioned report by the WHO, CBD is a safe substance with no potential for abuse. Similarly, CBD interacts with TRPV1 receptors by binding to their sites and blocking pain signals. CBD may also impact the nuclear receptor PPAR-gamma, which regulates the storage of fatty acids on top of glucose metabolism.
Why is taking CBD a potential risk for some people in recovery?
Alcohol abuse, opioid use, and stimulants are fast to develop a dependence—where the body needs the substance to function. Those who try to kick the habit can experience serious withdrawal symptoms, which can be life-threatening. Anyone can fall victim to alcohol or drug addiction or substance use disorder. Despite consequences on your health, relationships, or finances, becoming dependent on a substance means you seek it out to make you feel good or cope with everyday life.
Quitting smoking and drug withdrawal
Only using a product infrequently and keeping the dosage low are two ways that you can be proactive and reduce your chances of dependence. However, it’s important to note that the only way to avoid addiction to cannabis products entirely is not to use them. CUD typically results when individuals use products high in THC, meaning it’s not usually a concern for individuals who solely use CBD. While this is true, it’s important to keep an eye on any symptoms you may be experiencing and be honest with yourself. If you think CBD isn’t the right choice for you, you most likely won’t encounter any is cannabidiol addictive significant adverse effects by stopping use.
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